Mechanistic analysis of A46V, H57Y, and D129N in pyrazinamidase associated with pyrazinamide resistance

Pyrazinamide (PZA) is a component of first-line drugs, active against latent Mycobacterium tuberculosis (MTB) isolates. The prodrug is activated into the active form, pyrazinoic acid (POA) via pncA gene-encoded pyrazinamidase (PZase). Mutations in pncA have been reported, most commonly responsible f...

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Detalles Bibliográficos
Autores principales: Khan, Muhammad Tahir, Chinnasamy, Sathishkumar, Cui, Zhilei, Irfan, Muhammad, Wei, Dong-Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7569123/
https://www.ncbi.nlm.nih.gov/pubmed/33100877
http://dx.doi.org/10.1016/j.sjbs.2020.07.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7569123/
https://www.ncbi.nlm.nih.gov/pubmed/33100877
http://dx.doi.org/10.1016/j.sjbs.2020.07.015

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