Cargando…

Inhaled dry powder alginate oligosaccharide in cystic fibrosis: a randomised, double-blind, placebo-controlled, crossover phase 2b study

BACKGROUND: OligoG is a low molecular-weight alginate oligosaccharide that improves the viscoelastic properties of cystic fibrosis (CF) mucus and disrupts biofilms, thereby potentiating the activity of antimicrobial agents. The efficacy of inhaled OligoG was evaluated in adult patients with CF. METH...

Descripción completa

Detalles Bibliográficos
Autores principales:	van Koningsbruggen-Rietschel, Silke, Davies, Jane C., Pressler, Tacjana, Fischer, Rainald, MacGregor, Gordon, Donaldson, Scott H., Smerud, Knut, Meland, Nils, Mortensen, Jann, Fosbøl, Marie Ø., Downey, Damian G., Myrset, Astrid H., Flaten, Hugo, Rye, Philip D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	European Respiratory Society 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7569163/ https://www.ncbi.nlm.nih.gov/pubmed/33123558 http://dx.doi.org/10.1183/23120541.00132-2020

Ejemplares similares

Getting Near to “Closing the Gap” in the Pediatric Age Group for the First Personalized Treatment of Cystic Fibrosis
por: van Koningsbruggen-Rietschel, Silke
Publicado: (2021)

SARS-CoV-2 disrupts clinical research: the role of a rare disease-specific trial network
por: van Koningsbruggen-Rietschel, Silke, et al.
Publicado: (2020)

Review of recombinant human deoxyribonuclease (rhDNase) in the management of patients with cystic fibrosis
por: Pressler, Tacjana
Publicado: (2008)

Alginate oligosaccharides enhance diffusion and activity of colistin in a mucin-rich environment
por: Stokniene, Joana, et al.
Publicado: (2022)

Advances in Research on the Bioactivity of Alginate Oligosaccharides
por: Xing, Maochen, et al.
Publicado: (2020)

Alginate oligosaccharides enhance the antifungal activity of nystatin against candidal biofilms
por: Powell, Lydia C., et al.
Publicado: (2023)

Targeted disruption of the extracellular polymeric network of Pseudomonas aeruginosa biofilms by alginate oligosaccharides
por: Powell, Lydia C., et al.
Publicado: (2018)

From the infant to the geriatric patient—Strategies for inhalation therapy in asthma and chronic obstructive pulmonary disease
por: Hagmeyer, Lars, et al.
Publicado: (2023)

Alginate Oligosaccharides Affect Mechanical Properties and Antifungal Activity of Alginate Buccal Films with Posaconazole
por: Szekalska, Marta, et al.
Publicado: (2019)

Enzymatic Hydrolysis of Alginate to Produce Oligosaccharides by a New Purified Endo-Type Alginate Lyase
por: Zhu, Benwei, et al.
Publicado: (2016)

A Novel Cold-Adapted and High-Alkaline Alginate Lyase with Potential for Alginate Oligosaccharides Preparation
por: Wang, Hai-Ying, et al.
Publicado: (2023)

P062 Impact of the SARS-CoV-2 pandemic on clinical trials in the ECFS-CTN during 2020
por: Van Koningsbruggen-Rietschel, S., et al.
Publicado: (2021)

Structure–Activity Relationships of Low Molecular Weight Alginate Oligosaccharide Therapy against Pseudomonas aeruginosa
por: Pritchard, Manon F., et al.
Publicado: (2023)

Bi-Functional Alginate Oligosaccharide–Polymyxin Conjugates for Improved Treatment of Multidrug-Resistant Gram-Negative Bacterial Infections
por: Stokniene, Joana, et al.
Publicado: (2020)

Efficient Degradation of Alginate and Preparation of Alginate Oligosaccharides by a Novel Biofunctional Alginate Lyase with High Activity and Excellent Thermophilic Features
por: Li, Li, et al.
Publicado: (2023)

Alginate Oligosaccharides Inhibit Fungal Cell Growth and Potentiate the Activity of Antifungals against Candida and Aspergillus spp
por: Tøndervik, Anne, et al.
Publicado: (2014)

A Recombinant Alginate Lyase Algt1 with Potential in Preparing Alginate Oligosaccharides at High-Concentration Substrate
por: Liang, Qingping, et al.
Publicado: (2023)

Macroalga-Derived Alginate Oligosaccharide Alters Intestinal Bacteria of Atlantic Salmon
por: Gupta, Shruti, et al.
Publicado: (2019)

Identification of Critical Windows of Metabolic Programming of Metabolism and Lung Function in Male Offspring of Obese Dams
por: Dinger, Katharina, et al.
Publicado: (2020)

Alginate-Derived Oligosaccharide Inhibits Neuroinflammation and Promotes Microglial Phagocytosis of β-Amyloid
por: Zhou, Rui, et al.
Publicado: (2015)

Determination of oligosaccharide product distributions of PL7 alginate lyases by their structural elements
por: Zhang, Keke, et al.
Publicado: (2022)

An exploration of alginate oligosaccharides modulating intestinal inflammatory networks via gut microbiota
por: Zhang, Zhikai, et al.
Publicado: (2023)

Effects of Alginate Oligosaccharide on Testosterone-Induced Benign Prostatic Hyperplasia in Orchiectomized Rats
por: Jang, You-Jee, et al.
Publicado: (2023)

Protective Effects of Alginate and Chitosan Oligosaccharides against Clostridioides difficile Bacteria and Toxin
por: Mavrogeni, Maria Eleni, et al.
Publicado: (2023)

Living with cystic fibrosis – a qualitative study of a life coaching intervention
por: Knudsen, Karin Bæk, et al.
Publicado: (2018)

Alginate Oligosaccharide DP5 Exhibits Antitumor Effects in Osteosarcoma Patients following Surgery
por: Chen, Jiayu, et al.
Publicado: (2017)

Microbiota from alginate oligosaccharide-dosed mice successfully mitigated small intestinal mucositis
por: Zhang, Pengfei, et al.
Publicado: (2020)

Antimicrobial Activities of Alginate and Chitosan Oligosaccharides Against Staphylococcus aureus and Group B Streptococcus
por: Asadpoor, Mostafa, et al.
Publicado: (2021)

Alginate oligosaccharides can maintain activities of lysosomes under low pH condition
por: Park, Ra-Mi, et al.
Publicado: (2021)

Combined transcriptomic and metabolomic analysis of alginate oligosaccharides alleviating salt stress in rice seedlings
por: Du, You-Wei, et al.
Publicado: (2023)

Protecting clinical trials in cystic fibrosis during the SARS-CoV-2 pandemic: risks and mitigation measures
por: van Koningsbruggen-Rietschel, Silke, et al.
Publicado: (2021)

High-Level Expression of a Thermally Stable Alginate Lyase Using Pichia pastoris, Characterization and Application in Producing Brown Alginate Oligosaccharide
por: Li, Haifeng, et al.
Publicado: (2018)

Biochemical Characterization and Elucidation of the Hybrid Action Mode of a New Psychrophilic and Cold-Tolerant Alginate Lyase for Efficient Preparation of Alginate Oligosaccharides
por: Cao, Shengsheng, et al.
Publicado: (2022)

Improving the thermostability of alginate lyase FlAlyA with high expression by computer-aided rational design for industrial preparation of alginate oligosaccharides
por: Zhang, Xiu, et al.
Publicado: (2022)

Reduced neutrophil elastase inhibitor elafin and elevated transforming growth factor-β(1) are linked to inflammatory response in sputum of cystic fibrosis patients with Pseudomonas aeruginosa
por: Thomassen, Jan C., et al.
Publicado: (2021)

Severe Human Bocavirus Infection, Germany
por: Körner, Robert Walter, et al.
Publicado: (2011)

Alginate oligosaccharides improve germ cell development and testicular microenvironment to rescue busulfan disrupted spermatogenesis
por: Zhao, Yong, et al.
Publicado: (2020)

Single-cell RNA sequencing analysis reveals alginate oligosaccharides preventing chemotherapy-induced mucositis
por: Zhao, Yong, et al.
Publicado: (2020)

Rescue of male fertility following faecal microbiota transplantation from alginate oligosaccharide-dosed mice
por: Zhang, Cong, et al.
Publicado: (2021)

Alginate oligosaccharides increase boar semen quality by affecting gut microbiota and metabolites in blood and sperm
por: Han, Hui, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ovl4mokf4q8eaubjsfhnfm7t3f