MSC-Derived Exosomes Protect Vertebral Endplate Chondrocytes against Apoptosis and Calcification via the miR-31-5p/ATF6 Axis

Apoptosis and calcification of endplate chondrocytes (EPCs) can exacerbate intervertebral disc degeneration (IVDD). Mesenchymal stem cell-derived exosomes (MSC-exosomes) are reported to have the therapeutic potential in IVDD. However, the effects and related mechanisms of MSC-exosomes on EPCs are st...

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Detalles Bibliográficos
Autores principales: Xie, Lin, Chen, Zhenhao, Liu, Ming, Huang, Weibo, Zou, Fei, Ma, Xiaosheng, Tao, Jie, Guo, Jingkang, Xia, Xinlei, Lyu, Feizhou, Wang, Hongli, Zheng, Chaojun, Jiang, Jianyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7569190/
https://www.ncbi.nlm.nih.gov/pubmed/33230460
http://dx.doi.org/10.1016/j.omtn.2020.09.026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7569190/
https://www.ncbi.nlm.nih.gov/pubmed/33230460
http://dx.doi.org/10.1016/j.omtn.2020.09.026

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