Prolonged treatment with a PI3K p110α inhibitor causes sex- and tissue-dependent changes in antioxidant content, but does not affect mitochondrial function

Genetic inhibition of the p110α isoform of phosphatidylinositol-3-kinase (PI3K) can increase murine lifespan, enhance mitochondrial function and alter tissue-specific oxidative balance. Here, we investigated whether pharmacological inhibition of the p110α isoform of PI3K induces similar enhancement...

Descripción completa

Detalles Bibliográficos
Autores principales: Hedges, Christopher P., Pham, Toan, Shetty, Bhoopika, Masson, Stewart W.C., Hickey, Anthony J.R., Shepherd, Peter R., Merry, Troy L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2020
Materias:
Diabetes & Metabolic Disorders
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7569204/
https://www.ncbi.nlm.nih.gov/pubmed/33006363
http://dx.doi.org/10.1042/BSR20201128

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7569204/
https://www.ncbi.nlm.nih.gov/pubmed/33006363
http://dx.doi.org/10.1042/BSR20201128

Ejemplares similares