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Prolonged treatment with a PI3K p110α inhibitor causes sex- and tissue-dependent changes in antioxidant content, but does not affect mitochondrial function

Genetic inhibition of the p110α isoform of phosphatidylinositol-3-kinase (PI3K) can increase murine lifespan, enhance mitochondrial function and alter tissue-specific oxidative balance. Here, we investigated whether pharmacological inhibition of the p110α isoform of PI3K induces similar enhancement...

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Detalles Bibliográficos
Autores principales:	Hedges, Christopher P., Pham, Toan, Shetty, Bhoopika, Masson, Stewart W.C., Hickey, Anthony J.R., Shepherd, Peter R., Merry, Troy L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2020
Materias:	Diabetes & Metabolic Disorders
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7569204/ https://www.ncbi.nlm.nih.gov/pubmed/33006363 http://dx.doi.org/10.1042/BSR20201128

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