BPRDP056, a novel small molecule drug conjugate specifically targeting phosphatidylserine for cancer therapy

Zinc(II)-dipicolylamine (Zn-DPA) has been shown to specifically identify and bind to phosphatidylserine (PS), which exists in bulk in the tumor microenvironment. BPRDP056, a Zn-DPA-SN38 conjugate was designed to provide PS-targeted drug delivery of a cytotoxic SN38 to the tumor microenvironment, the...

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Detalles Bibliográficos
Autores principales: Chen, Yun-Yu, Lo, Chen-Fu, Chiu, Tai-Yu, Hsu, Chia-Yu, Yeh, Teng-Kuang, Chen, Ching-Ping, Huang, Chen-Lung, Huang, Chung-Yu, Wang, Min-Hsien, Huang, Yu-Chen, Ho, Hsuan-Hui, Chao, Yu-Sheng, Shih, Joe C., Tsou, Lun K., Chen, Chiung-Tong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7569237/
https://www.ncbi.nlm.nih.gov/pubmed/33069101
http://dx.doi.org/10.1016/j.tranon.2020.100897

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7569237/
https://www.ncbi.nlm.nih.gov/pubmed/33069101
http://dx.doi.org/10.1016/j.tranon.2020.100897

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