Brain transcriptome analysis reveals subtle effects on mitochondrial function and iron homeostasis of mutations in the SORL1 gene implicated in early onset familial Alzheimer’s disease

To prevent or delay the onset of Alzheimer’s disease (AD), we must understand its molecular basis. The great majority of AD cases arise sporadically with a late onset after 65 years of age (LOAD). However, rare familial cases of AD can occur due to dominant mutations in a small number of genes that...

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Detalles Bibliográficos
Autores principales: Barthelson, Karissa, Pederson, Stephen Martin, Newman, Morgan, Lardelli, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7570131/
https://www.ncbi.nlm.nih.gov/pubmed/33076949
http://dx.doi.org/10.1186/s13041-020-00681-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7570131/
https://www.ncbi.nlm.nih.gov/pubmed/33076949
http://dx.doi.org/10.1186/s13041-020-00681-7

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