Methylation of Methyl 4-Hydroxy-2-thioxo-1,2-dihydroquinoline-3-carboxylate: Synthetic, Crystallographic, and Molecular Docking Studies

Consecutive alkylation of 4-hydroxy-2-thioxo-1,2-dihydroquinoline-3-carboxylate by CH(3)I has been investigated to establish regioselectivity of the reaction for reliable design and synthesis of combinatorial libraries. In the first stage, the product of S-methylation-methyl 4-hydroxy-2-(methylthio)...

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Detalles Bibliográficos
Autores principales: Kovalenko, Sergiy M., Drushlyak, Oleksandr G., Shishkina, Svitlana V., Konovalova, Irina S., Mariutsa, Illia O., Bunyatyan, Natalya D., Kravchenko, Dmitry V., Ivanov, Vladimir V., Ivachtchenko, Alexandre V., Langer, Thierry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7570464/
https://www.ncbi.nlm.nih.gov/pubmed/32947763
http://dx.doi.org/10.3390/molecules25184238

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7570464/
https://www.ncbi.nlm.nih.gov/pubmed/32947763
http://dx.doi.org/10.3390/molecules25184238

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