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Wine’s Phenolic Compounds and Health: A Pythagorean View

In support of the J curve that describes the association between wine consumption and all-cause mortality, researchers and the lay press often advocate the health benefits of (poly)phenol consumption via red wine intake and cite the vast amount of in vitro literature that would corroborate the hypot...

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Autores principales: Visioli, Francesco, Panaite, Stefan-Alexandru, Tomé-Carneiro, Joao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7570485/
https://www.ncbi.nlm.nih.gov/pubmed/32911765
http://dx.doi.org/10.3390/molecules25184105
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author Visioli, Francesco
Panaite, Stefan-Alexandru
Tomé-Carneiro, Joao
author_facet Visioli, Francesco
Panaite, Stefan-Alexandru
Tomé-Carneiro, Joao
author_sort Visioli, Francesco
collection PubMed
description In support of the J curve that describes the association between wine consumption and all-cause mortality, researchers and the lay press often advocate the health benefits of (poly)phenol consumption via red wine intake and cite the vast amount of in vitro literature that would corroborate the hypothesis. Other researchers dismiss such evidence and call for total abstention. In this review, we take a skeptical, Pythagorean stance and we critically try to move the debate forward by pointing the readers to the many pitfalls of red wine (poly)phenol research, which we arbitrarily treat as if they were pharmacological agents. We conclude that, after 30 years of dedicated research and despite the considerable expenditure, we still lack solid, “pharmacological”, human evidence to confirm wine (poly)phenols’ biological actions. Future research will eventually clarify their activities and will back the current recommendations of responsibly drinking moderate amounts of wine with meals.
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spelling pubmed-75704852020-10-28 Wine’s Phenolic Compounds and Health: A Pythagorean View Visioli, Francesco Panaite, Stefan-Alexandru Tomé-Carneiro, Joao Molecules Review In support of the J curve that describes the association between wine consumption and all-cause mortality, researchers and the lay press often advocate the health benefits of (poly)phenol consumption via red wine intake and cite the vast amount of in vitro literature that would corroborate the hypothesis. Other researchers dismiss such evidence and call for total abstention. In this review, we take a skeptical, Pythagorean stance and we critically try to move the debate forward by pointing the readers to the many pitfalls of red wine (poly)phenol research, which we arbitrarily treat as if they were pharmacological agents. We conclude that, after 30 years of dedicated research and despite the considerable expenditure, we still lack solid, “pharmacological”, human evidence to confirm wine (poly)phenols’ biological actions. Future research will eventually clarify their activities and will back the current recommendations of responsibly drinking moderate amounts of wine with meals. MDPI 2020-09-08 /pmc/articles/PMC7570485/ /pubmed/32911765 http://dx.doi.org/10.3390/molecules25184105 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Visioli, Francesco
Panaite, Stefan-Alexandru
Tomé-Carneiro, Joao
Wine’s Phenolic Compounds and Health: A Pythagorean View
title Wine’s Phenolic Compounds and Health: A Pythagorean View
title_full Wine’s Phenolic Compounds and Health: A Pythagorean View
title_fullStr Wine’s Phenolic Compounds and Health: A Pythagorean View
title_full_unstemmed Wine’s Phenolic Compounds and Health: A Pythagorean View
title_short Wine’s Phenolic Compounds and Health: A Pythagorean View
title_sort wine’s phenolic compounds and health: a pythagorean view
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7570485/
https://www.ncbi.nlm.nih.gov/pubmed/32911765
http://dx.doi.org/10.3390/molecules25184105
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