Impact of Cholesterol on the Stability of Monomeric and Dimeric Forms of the Translocator Protein TSPO: A Molecular Simulation Study

The translocator protein (TSPO) is a transmembrane protein present across the three domains of life. Its functional quaternary structure consists of one or more subunits. In mice, the dimer-to-monomer equilibrium is shifted in vitro towards the monomer by adding cholesterol, a natural component of m...

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Detalles Bibliográficos
Autores principales: Si Chaib, Zeineb, Marchetto, Alessandro, Dishnica, Klevia, Carloni, Paolo, Giorgetti, Alejandro, Rossetti, Giulia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7570527/
https://www.ncbi.nlm.nih.gov/pubmed/32961709
http://dx.doi.org/10.3390/molecules25184299

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7570527/
https://www.ncbi.nlm.nih.gov/pubmed/32961709
http://dx.doi.org/10.3390/molecules25184299

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