Coupling of HSP72 α-Helix Subdomains by the Unexpected Irreversible Targeting of Lysine-56 over Cysteine-17; Coevolution of Covalent Bonding

Covalent inhibition has recently gained a resurgence of interest in several drug discovery areas. The expansion of this approach is based on evidence elucidating the selectivity and potency of covalent inhibitors when bound to particular amino acids of a biological target. The unexpected covalent in...

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Detalles Bibliográficos
Autores principales: Aljoundi, Aimen, El Rashedy, Ahmed, Appiah-Kubi, Patrick, Soliman, Mahmoud E. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7570744/
https://www.ncbi.nlm.nih.gov/pubmed/32947765
http://dx.doi.org/10.3390/molecules25184239

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7570744/
https://www.ncbi.nlm.nih.gov/pubmed/32947765
http://dx.doi.org/10.3390/molecules25184239

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