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Enhanced T-type calcium channel 3.2 activity in sensory neurons contributes to neuropathic-like pain of monosodium iodoacetate-induced knee osteoarthritis

The monosodium iodoacetate knee osteoarthritis model has been widely used for the evaluation of osteoarthritis pain, but the pathogenesis of associated chronic pain is not fully understood. The T-type calcium channel 3.2 (Ca(V)3.2) is abundantly expressed in the primary sensory neurons, in which it...

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Detalles Bibliográficos
Autores principales: Shin, Seung Min, Cai, Yongsong, Itson-Zoske, Brandon, Qiu, Chensheng, Hao, Xu, Xiang, Hongfei, Hogan, Quinn H, Yu, Hongwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7570798/
https://www.ncbi.nlm.nih.gov/pubmed/33054557
http://dx.doi.org/10.1177/1744806920963807