Probing the Highly Disparate Dual Inhibitory Mechanisms of Novel Quinazoline Derivatives against Mycobacterium tuberculosis Protein Kinases A and B

Mycobacterium tuberculosis (Mtb) serine/threonine (Ser/Thr) Protein kinases A (PknA) and B (PknB) have been identified as highly attractive targets for overcoming drug resistant tuberculosis. A recent lead series optimization study yielded compound 33 which exhibited potencies ~1000 times higher tha...

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Detalles Bibliográficos
Autores principales: Olotu, Fisayo A., Soliman, Mahmoud E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571077/
https://www.ncbi.nlm.nih.gov/pubmed/32947886
http://dx.doi.org/10.3390/molecules25184247

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571077/
https://www.ncbi.nlm.nih.gov/pubmed/32947886
http://dx.doi.org/10.3390/molecules25184247

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