Efficient Synthesis of α-Branched Purine-Based Acyclic Nucleosides: Scopes and Limitations of the Method

An efficient route to acylated acyclic nucleosides containing a branched hemiaminal ether moiety is reported via three-component alkylation of N-heterocycle (purine nucleobase) with acetal (cyclic or acyclic, variously branched) and anhydride (preferentially acetic anhydride). The procedure employs...

Descripción completa

Detalles Bibliográficos
Autores principales: Frydrych, Jan, Poštová Slavětínská, Lenka, Dračínský, Martin, Janeba, Zlatko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571146/
https://www.ncbi.nlm.nih.gov/pubmed/32961820
http://dx.doi.org/10.3390/molecules25184307

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571146/
https://www.ncbi.nlm.nih.gov/pubmed/32961820
http://dx.doi.org/10.3390/molecules25184307

Ejemplares similares