Design, Synthesis and Bioactivity Evaluation of 4,6-Disubstituted Pyrido[3,2-d]pyrimidine Derivatives as Mnk and HDAC Inhibitors

Both HDACs and Mnks play important role in translating multiple oncogenic signaling pathways during oncogenesis. As HDAC and Mnk are highly expressed in a variety of tumors; thus simultaneous inhibit HDAC and Mnk can increase the inhibition of tumor cell proliferation and provide a new way of inhibi...

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Detalles Bibliográficos
Autores principales: Xing, Kun, Zhang, Jian, Han, Yu, Tong, Tong, Liu, Dan, Zhao, Linxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571151/
https://www.ncbi.nlm.nih.gov/pubmed/32967084
http://dx.doi.org/10.3390/molecules25184318

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571151/
https://www.ncbi.nlm.nih.gov/pubmed/32967084
http://dx.doi.org/10.3390/molecules25184318

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