One Pot Synthesis of Micromolar BACE-1 Inhibitors Based on the Dihydropyrimidinone Scaffold and Their Thia and Imino Analogues

A library of dihydropyrimidinones was synthesized via a “one-pot” three component Biginelli reaction using different aldehydes in combination with β-dicarbonyl compounds and urea. Selected 2-thiooxo and 2-imino analogs were also obtained with the Biginelli reaction from thiourea and guanidine hydroc...

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Detalles Bibliográficos
Autores principales: Bais, Jessica, Benedetti, Fabio, Berti, Federico, Cerminara, Iole, Drioli, Sara, Funicello, Maria, Regini, Giorgia, Vidali, Mattia, Felluga, Fulvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571164/
https://www.ncbi.nlm.nih.gov/pubmed/32927879
http://dx.doi.org/10.3390/molecules25184152

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571164/
https://www.ncbi.nlm.nih.gov/pubmed/32927879
http://dx.doi.org/10.3390/molecules25184152

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