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One Pot Synthesis of Micromolar BACE-1 Inhibitors Based on the Dihydropyrimidinone Scaffold and Their Thia and Imino Analogues

A library of dihydropyrimidinones was synthesized via a “one-pot” three component Biginelli reaction using different aldehydes in combination with β-dicarbonyl compounds and urea. Selected 2-thiooxo and 2-imino analogs were also obtained with the Biginelli reaction from thiourea and guanidine hydroc...

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Detalles Bibliográficos
Autores principales:	Bais, Jessica, Benedetti, Fabio, Berti, Federico, Cerminara, Iole, Drioli, Sara, Funicello, Maria, Regini, Giorgia, Vidali, Mattia, Felluga, Fulvia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571164/ https://www.ncbi.nlm.nih.gov/pubmed/32927879 http://dx.doi.org/10.3390/molecules25184152

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