The Microbiota-Derived Metabolite of Quercetin, 3,4-Dihydroxyphenylacetic Acid Prevents Malignant Transformation and Mitochondrial Dysfunction Induced by Hemin in Colon Cancer and Normal Colon Epithelia Cell Lines

Meat diet plays a pivotal role in colorectal cancer (CRC). Hemin, a metabolite of myoglobin, produced after meat intake, has been involved in CRC initiation. The compound, 3,4-dihydroxyphenylacetic acid (3,4HPAA) is a scarcely studied microbiota-derived metabolite of the flavonoid quercetin (QUE), w...

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Detalles Bibliográficos
Autores principales: Catalán, Mabel, Ferreira, Jorge, Carrasco-Pozo, Catalina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571211/
https://www.ncbi.nlm.nih.gov/pubmed/32927689
http://dx.doi.org/10.3390/molecules25184138

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571211/
https://www.ncbi.nlm.nih.gov/pubmed/32927689
http://dx.doi.org/10.3390/molecules25184138

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