Extraocular Muscle Reveals Selective Vulnerability of Type IIB Fibers to Respiratory Chain Defects Induced by Mitochondrial DNA Alterations

PURPOSE: The purpose of this study was to gain insights on the pathogenesis of chronic progressive external ophthalmoplegia, thus we investigated the vulnerability of five extra ocular muscles (EOMs) fiber types to pathogenic mitochondrial DNA deletions in a mouse model expressing a mutated mitochon...

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Detalles Bibliográficos
Autores principales: Oexner, Rafael R., Pla-Martín, David, Paß, Thomas, Wiesen, Martin H. J., Zentis, Peter, Schauss, Astrid, Baris, Olivier R., Kimoloi, Sammy, Wiesner, Rudolf J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2020
Materias:
Biochemistry and Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571275/
https://www.ncbi.nlm.nih.gov/pubmed/33057669
http://dx.doi.org/10.1167/iovs.61.12.14

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571275/
https://www.ncbi.nlm.nih.gov/pubmed/33057669
http://dx.doi.org/10.1167/iovs.61.12.14

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