Ebselen, Disulfiram, Carmofur, PX-12, Tideglusib, and Shikonin Are Nonspecific Promiscuous SARS-CoV-2 Main Protease Inhibitors

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[Image: see text] Among the drug targets being investigated for SARS-CoV-2, the viral main protease (M(pro)) is one of the most extensively studied. M(pro) is a cysteine protease that hydrolyzes the viral polyprotein at more than 11 sites. It is highly conserved and has a unique substrate preference...

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Detalles Bibliográficos
Autores principales: Ma, Chunlong, Hu, Yanmei, Townsend, Julia Alma, Lagarias, Panagiotis I., Marty, Michael Thomas, Kolocouris, Antonios, Wang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571300/
https://www.ncbi.nlm.nih.gov/pubmed/33330841
http://dx.doi.org/10.1021/acsptsci.0c00130

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571300/
https://www.ncbi.nlm.nih.gov/pubmed/33330841
http://dx.doi.org/10.1021/acsptsci.0c00130

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