Endothelial BMPR2 Loss Drives a Proliferative Response to BMP (Bone Morphogenetic Protein) 9 via Prolonged Canonical Signaling

Pulmonary arterial hypertension is a disease of proliferative vascular occlusion that is strongly linked to mutations in BMPR2—the gene encoding the BMPR-II (BMP [bone morphogenetic protein] type II receptor). The endothelial-selective BMPR-II ligand, BMP9, reverses disease in animal models of pulmo...

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Detalles Bibliográficos
Autores principales: Theilmann, Anne L., Hawke, Lindsey G., Hilton, L. Rhiannon, Whitford, Mara K.M., Cole, Devon V., Mackeil, Jodi L., Dunham-Snary, Kimberly J., Mewburn, Jeffrey, James, Paula D., Maurice, Donald H., Archer, Stephen L., Ormiston, Mark L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Basic Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571847/
https://www.ncbi.nlm.nih.gov/pubmed/32998516
http://dx.doi.org/10.1161/ATVBAHA.119.313357

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571847/
https://www.ncbi.nlm.nih.gov/pubmed/32998516
http://dx.doi.org/10.1161/ATVBAHA.119.313357

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