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Endothelial BMPR2 Loss Drives a Proliferative Response to BMP (Bone Morphogenetic Protein) 9 via Prolonged Canonical Signaling

Pulmonary arterial hypertension is a disease of proliferative vascular occlusion that is strongly linked to mutations in BMPR2—the gene encoding the BMPR-II (BMP [bone morphogenetic protein] type II receptor). The endothelial-selective BMPR-II ligand, BMP9, reverses disease in animal models of pulmo...

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Detalles Bibliográficos
Autores principales:	Theilmann, Anne L., Hawke, Lindsey G., Hilton, L. Rhiannon, Whitford, Mara K.M., Cole, Devon V., Mackeil, Jodi L., Dunham-Snary, Kimberly J., Mewburn, Jeffrey, James, Paula D., Maurice, Donald H., Archer, Stephen L., Ormiston, Mark L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2020
Materias:	Basic Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571847/ https://www.ncbi.nlm.nih.gov/pubmed/32998516 http://dx.doi.org/10.1161/ATVBAHA.119.313357

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