Pathogenic germline variants are associated with poor survival in stage III/IV melanoma patients

Patients with late stage resected cutaneous melanoma have poor overall survival (OS) and experience irreversible adverse events from systemic therapy. There is a clinical need to identify biomarkers to predict outcome. Performing germline/tumour whole-exome sequencing of 44 stage III/IV melanoma pat...

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Detalles Bibliográficos
Autores principales: Aoude, Lauren G., Bonazzi, Vanessa F., Brosda, Sandra, Patel, Kalpana, Koufariotis, Lambros T., Oey, Harald, Nones, Katia, Wood, Scott, Pearson, John V., Lonie, James M., Arneil, Melissa, Atkinson, Victoria, Smithers, B. Mark, Waddell, Nicola, Barbour, Andrew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7572377/
https://www.ncbi.nlm.nih.gov/pubmed/33077847
http://dx.doi.org/10.1038/s41598-020-74956-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7572377/
https://www.ncbi.nlm.nih.gov/pubmed/33077847
http://dx.doi.org/10.1038/s41598-020-74956-3

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