Pharmacological ascorbate inhibits pancreatic cancer metastases via a peroxide-mediated mechanism

Pharmacological ascorbate (P-AscH(−), high-dose, intravenous vitamin C) is cytotoxic to tumor cells in doses achievable in humans. Phase I studies in pancreatic cancer (PDAC) utilizing P-AscH(−) have demonstrated increases in progression free survival, suggesting a reduction in metastatic disease bu...

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Detalles Bibliográficos
Autores principales: O’Leary, Brianne R., Alexander, Matthew S., Du, Juan, Moose, Devon L., Henry, Michael D., Cullen, Joseph J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7572461/
https://www.ncbi.nlm.nih.gov/pubmed/33077776
http://dx.doi.org/10.1038/s41598-020-74806-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7572461/
https://www.ncbi.nlm.nih.gov/pubmed/33077776
http://dx.doi.org/10.1038/s41598-020-74806-2

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