Prediction of genome-wide effects of single nucleotide variants on transcription factor binding

Single nucleotide variants (SNVs) located in transcriptional regulatory regions can result in gene expression changes that lead to adaptive or detrimental phenotypic outcomes. Here, we predict gain or loss of binding sites for 741 transcription factors (TFs) across the human genome. We calculated ‘g...

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Detalles Bibliográficos
Autores principales: Carrasco Pro, Sebastian, Bulekova, Katia, Gregor, Brian, Labadorf, Adam, Fuxman Bass, Juan Ignacio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7572467/
https://www.ncbi.nlm.nih.gov/pubmed/33077858
http://dx.doi.org/10.1038/s41598-020-74793-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7572467/
https://www.ncbi.nlm.nih.gov/pubmed/33077858
http://dx.doi.org/10.1038/s41598-020-74793-4

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