Manumycin Polyketides Act as Molecular Glues Between UBR7 and P53

Molecular glues are an intriguing therapeutic modality that harness small-molecules to induce interactions between proteins that typically do not interact. However, such molecules are rare and have been discovered fortuitously, thus limiting their potential as a general strategy for therapeutic inte...

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Detalles Bibliográficos
Autores principales: Isobe, Yosuke, Okumura, Mikiko, McGregor, Lynn M., Brittain, Scott M., Jones, Michael D., Liang, Xiaoyou, White, Ross, Forrester, William, McKenna, Jeffrey M., Tallarico, John A., Schirle, Markus, Maimone, Thomas J., Nomura, Daniel K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7572527/
https://www.ncbi.nlm.nih.gov/pubmed/32572277
http://dx.doi.org/10.1038/s41589-020-0557-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7572527/
https://www.ncbi.nlm.nih.gov/pubmed/32572277
http://dx.doi.org/10.1038/s41589-020-0557-2

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