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Manumycin Polyketides Act as Molecular Glues Between UBR7 and P53
Molecular glues are an intriguing therapeutic modality that harness small-molecules to induce interactions between proteins that typically do not interact. However, such molecules are rare and have been discovered fortuitously, thus limiting their potential as a general strategy for therapeutic inte...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7572527/ https://www.ncbi.nlm.nih.gov/pubmed/32572277 http://dx.doi.org/10.1038/s41589-020-0557-2 |