Blocking of efflux transporters in rats improves translational validation of brain radioligands

BACKGROUND: Positron emission tomography (PET) is a molecular imaging technique that can be used to investigate the in vivo pharmacology of drugs. Initial preclinical evaluation of PET tracers is often conducted in rodents due to the accessibility of disease models as well as economic considerations...

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Detalles Bibliográficos
Autores principales: Shalgunov, Vladimir, Xiong, Mengfei, L’Estrade, Elina T., Raval, Nakul R., Andersen, Ida V., Edgar, Fraser G., Speth, Nikolaj R., Baerentzen, Simone L., Hansen, Hanne D., Donovan, Lene L., Nasser, Arafat, Peitersen, Siv T., Kjaer, Andreas, Knudsen, Gitte M., Syvänen, Stina, Palner, Mikael, Herth, Matthias M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7572968/
https://www.ncbi.nlm.nih.gov/pubmed/33074370
http://dx.doi.org/10.1186/s13550-020-00718-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7572968/
https://www.ncbi.nlm.nih.gov/pubmed/33074370
http://dx.doi.org/10.1186/s13550-020-00718-x

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