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Non-viral Gene Delivery of Interleukin-1 Receptor Antagonist Using Collagen-Hydroxyapatite Scaffold Protects Rat BM-MSCs From IL-1β-Mediated Inhibition of Osteogenesis

Although most bone fractures typically heal without complications, a small proportion of patients (≤10%) experience delayed healing or potential progression to non-union. Interleukin-1 (IL-1β) plays a crucial role in fracture healing as an early driver of inflammation. However, the effects of IL-1β...

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Detalles Bibliográficos
Autores principales: Lackington, William A., Gomez-Sierra, Maria Antonia, González-Vázquez, Arlyng, O’Brien, Fergal J., Stoddart, Martin J., Thompson, Keith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573213/
https://www.ncbi.nlm.nih.gov/pubmed/33123517
http://dx.doi.org/10.3389/fbioe.2020.582012