Caffeine Targets G6PDH to Disrupt Redox Homeostasis and Inhibit Renal Cell Carcinoma Proliferation

Glucose-6-phosphate dehydrogenase (G6PDH) is the rate-limiting enzyme in the pentose phosphate pathway (PPP) and plays a crucial role in the maintenance of redox homeostasis by producing nicotinamide adenine dinucleotide phosphate (NADPH), the major intracellular reductant. G6PDH has been shown to b...

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Detalles Bibliográficos
Autores principales: Xu, Huanhuan, Hu, Lihong, Liu, Titi, Chen, Fei, Li, Jin, Xu, Jing, Jiang, Li, Xiang, Zemin, Wang, Xuanjun, Sheng, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573228/
https://www.ncbi.nlm.nih.gov/pubmed/33123534
http://dx.doi.org/10.3389/fcell.2020.556162

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573228/
https://www.ncbi.nlm.nih.gov/pubmed/33123534
http://dx.doi.org/10.3389/fcell.2020.556162

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