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Helpless Priming Sends CD8(+) T Cells on the Road to Exhaustion
Persistent antigen exposure in chronic infection and cancer has been proposed to lead to cytotoxic T lymphocyte (CTL) “exhaustion”, i.e., loss of effector function and disease control. Recent work identifies a population of poorly differentiated TCF-1(+)PD-1(+) CD8(+) T cells as precursors of the te...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573232/ https://www.ncbi.nlm.nih.gov/pubmed/33123174 http://dx.doi.org/10.3389/fimmu.2020.592569 |