Lactate Suppresses Macrophage Pro-Inflammatory Response to LPS Stimulation by Inhibition of YAP and NF-κB Activation via GPR81-Mediated Signaling

Recent evidence from cancer research indicates that lactate exerts a suppressive effect on innate immune responses in cancer. This study investigated the mechanisms by which lactate suppresses macrophage pro-inflammatory responses. Macrophages [Raw 264.7 and bone marrow derived macrophages (BMDMs)]...

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Detalles Bibliográficos
Autores principales: Yang, Kun, Xu, Jingjing, Fan, Min, Tu, Fei, Wang, Xiaohui, Ha, Tuanzhu, Williams, David L., Li, Chuanfu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573489/
https://www.ncbi.nlm.nih.gov/pubmed/33123172
http://dx.doi.org/10.3389/fimmu.2020.587913

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573489/
https://www.ncbi.nlm.nih.gov/pubmed/33123172
http://dx.doi.org/10.3389/fimmu.2020.587913

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