Obesity-Associated Myeloid-Derived Suppressor Cells Promote Apoptosis of Tumor-Infiltrating CD8 T Cells and Immunotherapy Resistance in Breast Cancer

Nearly 70% of adults in the US are currently overweight or obese. Despite such high prevalence, the impact of obesity on antitumor immunity and immunotherapy outcomes remains incompletely understood, particularly in patients with breast cancer. Here, we addressed these gaps in knowledge using two mu...

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Detalles Bibliográficos
Autores principales: Gibson, Justin T., Orlandella, Rachael M., Turbitt, William J., Behring, Michael, Manne, Upender, Sorge, Robert E., Norian, Lyse A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573510/
https://www.ncbi.nlm.nih.gov/pubmed/33123173
http://dx.doi.org/10.3389/fimmu.2020.590794

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573510/
https://www.ncbi.nlm.nih.gov/pubmed/33123173
http://dx.doi.org/10.3389/fimmu.2020.590794

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