Respiratory Supercomplexes Promote Mitochondrial Efficiency and Growth in Severely Hypoxic Pancreatic Cancer

Pancreatic ductal adenocarcinoma (PDAC) is characterized by extensive fibrosis and hypovascularization, resulting in significant intratumoral hypoxia (low oxygen) that contributes to its aggressiveness, therapeutic resistance, and high mortality. Despite oxygen being a fundamental requirement for ma...

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Detalles Bibliográficos
Autores principales: Hollinshead, Kate E.R., Parker, Seth J., Eapen, Vinay V., Encarnacion-Rosado, Joel, Sohn, Albert, Oncu, Tugba, Cammer, Michael, Mancias, Joseph D., Kimmelman, Alec C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573785/
https://www.ncbi.nlm.nih.gov/pubmed/33027658
http://dx.doi.org/10.1016/j.celrep.2020.108231

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573785/
https://www.ncbi.nlm.nih.gov/pubmed/33027658
http://dx.doi.org/10.1016/j.celrep.2020.108231

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