IgM autoantibodies recognizing ACE2 are associated with severe COVID-19

SARS-CoV-2 infection induces severe disease in a subpopulation of patients, but the underlying mechanisms remain unclear. We demonstrate robust IgM autoantibodies that recognize angiotensin converting enzyme-2 (ACE2) in 18/66 (27%) patients with severe COVID-19, which are rare (2/52; 3.8%) in hospit...

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Detalles Bibliográficos
Autores principales: Casciola-Rosen, Livia, Thiemann, David R., Andrade, Felipe, Trejo Zambrano, Maria Isabel, Hooper, Jody E., Leonard, Elissa K., Spangler, Jamie B., Cox, Andrea L., Machamer, Carolyn E., Sauer, Lauren, Laeyendecker, Oliver, Garibaldi, Brian T., Ray, Stuart C., Mecoli, Christopher A., Christopher-Stine, Lisa, Gutierrez-Alamillo, Laura, Yang, Qingyuan, Hines, David, Clarke, William A., Rothman, Richard, Pekosz, Andrew, Fenstermacher, Katherine J., Wang, Zitong, Zeger, Scott L., Rosen, Antony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574257/
https://www.ncbi.nlm.nih.gov/pubmed/33083808
http://dx.doi.org/10.1101/2020.10.13.20211664

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574257/
https://www.ncbi.nlm.nih.gov/pubmed/33083808
http://dx.doi.org/10.1101/2020.10.13.20211664

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