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DNMT1-mediated methylation inhibits microRNA-214-3p and promotes hair follicle stem cell differentiate into adipogenic lineages

BACKGROUND: Dysfunction of the DNA methylation was associated with stem cell reprogramming. Moreover, DNA methyltransferase 1 (DNMT1) deficiency was involved in the differentiation of hair follicle stem cell (HFSc), but the molecular mechanisms remain unknown. METHODS: HFSc from human scalp tissues...

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Detalles Bibliográficos
Autores principales: Jin, Fangcao, Li, Min, Li, Xuyang, Zheng, Yunpeng, Zhang, Kun, Liu, Xiaojun, Cai, Bingjie, Yin, Guangwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574326/
https://www.ncbi.nlm.nih.gov/pubmed/33076979
http://dx.doi.org/10.1186/s13287-020-01864-8