Synthesis of an Oxathiolane Drug Substance Intermediate Guided by Constraint-Driven Innovation

[Image: see text] A new route was developed for construction of the oxathiolane intermediate used in the synthesis of lamivudine (3TC) and emtricitabine (FTC). We developed the presented route by constraining ourselves to low-cost, widely available starting materials—we refer to this as supply-cente...

Descripción completa

Detalles Bibliográficos
Autores principales: Kashinath, K., Snead, David R., Burns, Justina M., Stringham, Rodger W., Gupton, B. Frank, McQuade, D. Tyler
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574620/
https://www.ncbi.nlm.nih.gov/pubmed/33100812
http://dx.doi.org/10.1021/acs.oprd.0c00145

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574620/
https://www.ncbi.nlm.nih.gov/pubmed/33100812
http://dx.doi.org/10.1021/acs.oprd.0c00145

Ejemplares similares