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Synthesis of an Oxathiolane Drug Substance Intermediate Guided by Constraint-Driven Innovation
[Image: see text] A new route was developed for construction of the oxathiolane intermediate used in the synthesis of lamivudine (3TC) and emtricitabine (FTC). We developed the presented route by constraining ourselves to low-cost, widely available starting materials—we refer to this as supply-cente...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American
Chemical Society
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574620/ https://www.ncbi.nlm.nih.gov/pubmed/33100812 http://dx.doi.org/10.1021/acs.oprd.0c00145 |