GLT-1 Knockdown Inhibits Ceftriaxone-Mediated Improvements on Cognitive Deficits, and GLT-1 and xCT Expression and Activity in APP/PS1 AD Mice

OBJECTIVE: Glutamate transporter-1 (GLT-1) and system x(c)(–) mediate glutamate uptake and release, respectively. Ceftriaxone has been reported to upregulate GLT-1 expression and improve cognitive decline in APP/PS1 mice. The aim of the present study was to elucidate the role of GLT-1 in ceftriaxone...

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Detalles Bibliográficos
Autores principales: Gao, JunXia, Liu, LiZhe, Liu, Chao, Fan, ShuJuan, Liu, LiRong, Liu, ShuFeng, Xian, Xiao-Hui, Li, Wen-Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574737/
https://www.ncbi.nlm.nih.gov/pubmed/33132901
http://dx.doi.org/10.3389/fnagi.2020.580772

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574737/
https://www.ncbi.nlm.nih.gov/pubmed/33132901
http://dx.doi.org/10.3389/fnagi.2020.580772

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