CMTR1-Catalyzed 2′-O-Ribose Methylation Controls Neuronal Development by Regulating Camk2α Expression Independent of RIG-I Signaling

Eukaryotic mRNAs are 5′ end capped with a 7-methylguanosine, which is important for processing and translation of mRNAs. Cap methyltransferase 1 (CMTR1) catalyzes 2′-O-ribose methylation of the first transcribed nucleotide (N1 2′-O-Me) to mask mRNAs from innate immune surveillance by retinoic-acid-i...

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Detalles Bibliográficos
Autores principales: Lee, Yen-Lurk, Kung, Fan-Che, Lin, Chia-Hsuan, Huang, Yi-Shuian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). 2020
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574844/
https://www.ncbi.nlm.nih.gov/pubmed/33086056
http://dx.doi.org/10.1016/j.celrep.2020.108269

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574844/
https://www.ncbi.nlm.nih.gov/pubmed/33086056
http://dx.doi.org/10.1016/j.celrep.2020.108269

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