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Unbiased Screens Show CD8(+) T Cells of COVID-19 Patients Recognize Shared Epitopes in SARS-CoV-2 that Largely Reside outside the Spike Protein

Developing effective strategies to prevent or treat coronavirus disease 2019 (COVID-19) requires understanding the natural immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We used an unbiased, genome-wide screening technology to determine the precise peptide sequences...

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Detalles Bibliográficos
Autores principales: Ferretti, Andrew P., Kula, Tomasz, Wang, Yifan, Nguyen, Dalena M.V., Weinheimer, Adam, Dunlap, Garrett S., Xu, Qikai, Nabilsi, Nancy, Perullo, Candace R., Cristofaro, Alexander W., Whitton, Holly J., Virbasius, Amy, Olivier, Kenneth J., Buckner, Lyndsey R., Alistar, Angela T., Whitman, Eric D., Bertino, Sarah A., Chattopadhyay, Shrikanta, MacBeath, Gavin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574860/
https://www.ncbi.nlm.nih.gov/pubmed/33128877
http://dx.doi.org/10.1016/j.immuni.2020.10.006