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New computational protein design methods for de novo small molecule binding sites
Protein binding to small molecules is fundamental to many biological processes, yet it remains challenging to predictively design this functionality de novo. Current state-of-the-art computational design methods typically rely on existing small molecule binding sites or protein scaffolds with existi...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575090/ https://www.ncbi.nlm.nih.gov/pubmed/33017412 http://dx.doi.org/10.1371/journal.pcbi.1008178 |