Poxvirus-encoded decapping enzymes promote selective translation of viral mRNAs

Cellular decapping enzymes negatively regulate gene expression by removing the methylguanosine cap at the 5’ end of eukaryotic mRNA, rendering mRNA susceptible to degradation and repressing mRNA translation. Vaccinia virus (VACV), the prototype poxvirus, encodes two decapping enzymes, D9 and D10, th...

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Detalles Bibliográficos
Autores principales: Cantu, Fernando, Cao, Shuai, Hernandez, Candy, Dhungel, Pragyesh, Spradlin, Joshua, Yang, Zhilong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575113/
https://www.ncbi.nlm.nih.gov/pubmed/33031446
http://dx.doi.org/10.1371/journal.ppat.1008926

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575113/
https://www.ncbi.nlm.nih.gov/pubmed/33031446
http://dx.doi.org/10.1371/journal.ppat.1008926

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