Luminespib counteracts the Kifunensine-induced lung endothelial barrier dysfunction

Unfolded protein response (UPR) suppression by Kifunensine has been associated with lung hyperpermeability, the hallmark of Acute Respiratory Distress Syndrome. The present study investigates the effects of the heat shock protein 90 inhibitor Luminespib (AUY-922) towards the Kifunensine-triggered lu...

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Autores principales: Kubra, Khadeja-Tul, Uddin, Mohammad A., Akhter, Mohammad S., Barabutis, Nektarios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575137/
https://www.ncbi.nlm.nih.gov/pubmed/33094291
http://dx.doi.org/10.1016/j.crtox.2020.09.003
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author Kubra, Khadeja-Tul
Uddin, Mohammad A.
Akhter, Mohammad S.
Barabutis, Nektarios
author_facet Kubra, Khadeja-Tul
Uddin, Mohammad A.
Akhter, Mohammad S.
Barabutis, Nektarios
author_sort Kubra, Khadeja-Tul
collection PubMed
description Unfolded protein response (UPR) suppression by Kifunensine has been associated with lung hyperpermeability, the hallmark of Acute Respiratory Distress Syndrome. The present study investigates the effects of the heat shock protein 90 inhibitor Luminespib (AUY-922) towards the Kifunensine-triggered lung endothelial dysfunction. Our results indicate that the UPR inducer Luminespib counteracts the effects of Kifunensine in both human and bovine lung endothelial cells. Hence, we suggest that mild UPR induction may serve as a promising therapeutic strategy against potentially lethal respiratory disorders, including the ARDS related to COVID-19.
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spelling pubmed-75751372021-06-10 Luminespib counteracts the Kifunensine-induced lung endothelial barrier dysfunction Kubra, Khadeja-Tul Uddin, Mohammad A. Akhter, Mohammad S. Barabutis, Nektarios Curr Res Toxicol Article Unfolded protein response (UPR) suppression by Kifunensine has been associated with lung hyperpermeability, the hallmark of Acute Respiratory Distress Syndrome. The present study investigates the effects of the heat shock protein 90 inhibitor Luminespib (AUY-922) towards the Kifunensine-triggered lung endothelial dysfunction. Our results indicate that the UPR inducer Luminespib counteracts the effects of Kifunensine in both human and bovine lung endothelial cells. Hence, we suggest that mild UPR induction may serve as a promising therapeutic strategy against potentially lethal respiratory disorders, including the ARDS related to COVID-19. Elsevier 2020-09-24 /pmc/articles/PMC7575137/ /pubmed/33094291 http://dx.doi.org/10.1016/j.crtox.2020.09.003 Text en © 2020 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Kubra, Khadeja-Tul
Uddin, Mohammad A.
Akhter, Mohammad S.
Barabutis, Nektarios
Luminespib counteracts the Kifunensine-induced lung endothelial barrier dysfunction
title Luminespib counteracts the Kifunensine-induced lung endothelial barrier dysfunction
title_full Luminespib counteracts the Kifunensine-induced lung endothelial barrier dysfunction
title_fullStr Luminespib counteracts the Kifunensine-induced lung endothelial barrier dysfunction
title_full_unstemmed Luminespib counteracts the Kifunensine-induced lung endothelial barrier dysfunction
title_short Luminespib counteracts the Kifunensine-induced lung endothelial barrier dysfunction
title_sort luminespib counteracts the kifunensine-induced lung endothelial barrier dysfunction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575137/
https://www.ncbi.nlm.nih.gov/pubmed/33094291
http://dx.doi.org/10.1016/j.crtox.2020.09.003
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