The pan-Bcl-2 inhibitor obatoclax promotes differentiation and apoptosis of acute myeloid leukemia cells

One of the key features of acute myeloid leukemia (AML) is the arrest of differentiation at the early progenitor stage of myelopoiesis. Therefore, the identification of new agents that could overcome this differentiation block and force leukemic cells to enter the apoptotic pathway is essential for...

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Detalles Bibliográficos
Autores principales: Opydo-Chanek, Małgorzata, Cichoń, Iwona, Rak, Agnieszka, Kołaczkowska, Elżbieta, Mazur, Lidia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Preclinical Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575496/
https://www.ncbi.nlm.nih.gov/pubmed/32367199
http://dx.doi.org/10.1007/s10637-020-00931-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575496/
https://www.ncbi.nlm.nih.gov/pubmed/32367199
http://dx.doi.org/10.1007/s10637-020-00931-4

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