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WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion

Melanoma is a highly aggressive tumour that can metastasize very early in disease progression. Notably, melanoma can disseminate using amoeboid invasive strategies. We show here that high Myosin II activity, high levels of ki-67 and high tumour-initiating abilities are characteristic of invasive amo...

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Autores principales: Rodriguez-Hernandez, Irene, Maiques, Oscar, Kohlhammer, Leonie, Cantelli, Gaia, Perdrix-Rosell, Anna, Monger, Joanne, Fanshawe, Bruce, Bridgeman, Victoria L., Karagiannis, Sophia N., Penin, Rosa M., Marcolval, Joaquim, Marti, Rosa M., Matias-Guiu, Xavier, Fruhwirth, Gilbert O., Orgaz, Jose L., Malanchi, Ilaria, Sanz-Moreno, Victoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575593/
https://www.ncbi.nlm.nih.gov/pubmed/33082334
http://dx.doi.org/10.1038/s41467-020-18951-2
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author Rodriguez-Hernandez, Irene
Maiques, Oscar
Kohlhammer, Leonie
Cantelli, Gaia
Perdrix-Rosell, Anna
Monger, Joanne
Fanshawe, Bruce
Bridgeman, Victoria L.
Karagiannis, Sophia N.
Penin, Rosa M.
Marcolval, Joaquim
Marti, Rosa M.
Matias-Guiu, Xavier
Fruhwirth, Gilbert O.
Orgaz, Jose L.
Malanchi, Ilaria
Sanz-Moreno, Victoria
author_facet Rodriguez-Hernandez, Irene
Maiques, Oscar
Kohlhammer, Leonie
Cantelli, Gaia
Perdrix-Rosell, Anna
Monger, Joanne
Fanshawe, Bruce
Bridgeman, Victoria L.
Karagiannis, Sophia N.
Penin, Rosa M.
Marcolval, Joaquim
Marti, Rosa M.
Matias-Guiu, Xavier
Fruhwirth, Gilbert O.
Orgaz, Jose L.
Malanchi, Ilaria
Sanz-Moreno, Victoria
author_sort Rodriguez-Hernandez, Irene
collection PubMed
description Melanoma is a highly aggressive tumour that can metastasize very early in disease progression. Notably, melanoma can disseminate using amoeboid invasive strategies. We show here that high Myosin II activity, high levels of ki-67 and high tumour-initiating abilities are characteristic of invasive amoeboid melanoma cells. Mechanistically, we find that WNT11-FZD7-DAAM1 activates Rho-ROCK1/2-Myosin II and plays a crucial role in regulating tumour-initiating potential, local invasion and distant metastasis formation. Importantly, amoeboid melanoma cells express both proliferative and invasive gene signatures. As such, invasive fronts of human and mouse melanomas are enriched in amoeboid cells that are also ki-67 positive. This pattern is further enhanced in metastatic lesions. We propose eradication of amoeboid melanoma cells after surgical removal as a therapeutic strategy.
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spelling pubmed-75755932020-10-29 WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion Rodriguez-Hernandez, Irene Maiques, Oscar Kohlhammer, Leonie Cantelli, Gaia Perdrix-Rosell, Anna Monger, Joanne Fanshawe, Bruce Bridgeman, Victoria L. Karagiannis, Sophia N. Penin, Rosa M. Marcolval, Joaquim Marti, Rosa M. Matias-Guiu, Xavier Fruhwirth, Gilbert O. Orgaz, Jose L. Malanchi, Ilaria Sanz-Moreno, Victoria Nat Commun Article Melanoma is a highly aggressive tumour that can metastasize very early in disease progression. Notably, melanoma can disseminate using amoeboid invasive strategies. We show here that high Myosin II activity, high levels of ki-67 and high tumour-initiating abilities are characteristic of invasive amoeboid melanoma cells. Mechanistically, we find that WNT11-FZD7-DAAM1 activates Rho-ROCK1/2-Myosin II and plays a crucial role in regulating tumour-initiating potential, local invasion and distant metastasis formation. Importantly, amoeboid melanoma cells express both proliferative and invasive gene signatures. As such, invasive fronts of human and mouse melanomas are enriched in amoeboid cells that are also ki-67 positive. This pattern is further enhanced in metastatic lesions. We propose eradication of amoeboid melanoma cells after surgical removal as a therapeutic strategy. Nature Publishing Group UK 2020-10-20 /pmc/articles/PMC7575593/ /pubmed/33082334 http://dx.doi.org/10.1038/s41467-020-18951-2 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Rodriguez-Hernandez, Irene
Maiques, Oscar
Kohlhammer, Leonie
Cantelli, Gaia
Perdrix-Rosell, Anna
Monger, Joanne
Fanshawe, Bruce
Bridgeman, Victoria L.
Karagiannis, Sophia N.
Penin, Rosa M.
Marcolval, Joaquim
Marti, Rosa M.
Matias-Guiu, Xavier
Fruhwirth, Gilbert O.
Orgaz, Jose L.
Malanchi, Ilaria
Sanz-Moreno, Victoria
WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion
title WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion
title_full WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion
title_fullStr WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion
title_full_unstemmed WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion
title_short WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion
title_sort wnt11-fzd7-daam1 signalling supports tumour initiating abilities and melanoma amoeboid invasion
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575593/
https://www.ncbi.nlm.nih.gov/pubmed/33082334
http://dx.doi.org/10.1038/s41467-020-18951-2
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