Modeling Klinefelter Syndrome Using Induced Pluripotent Stem Cells Reveals Impaired Germ Cell Differentiation

Klinefelter syndrome (KS), with an incidence between 1/600 and 1/1,000, is the main genetic cause of male infertility. Due to the lack of an accurate study model, the detailed pathogenic mechanisms by which this X chromosome aneuploidy leads to KS features remain unknown. Here, we report the generat...

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Detalles Bibliográficos
Autores principales: Botman, Olivier, Hibaoui, Youssef, Giudice, Maria G., Ambroise, Jérôme, Creppe, Catherine, Feki, Anis, Wyns, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575714/
https://www.ncbi.nlm.nih.gov/pubmed/33117798
http://dx.doi.org/10.3389/fcell.2020.567454

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575714/
https://www.ncbi.nlm.nih.gov/pubmed/33117798
http://dx.doi.org/10.3389/fcell.2020.567454

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