Cargando…

Diclofenac impairs autophagic flux via oxidative stress and lysosomal dysfunction: Implications for hepatotoxicity

Treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with various side effects, including cardiovascular and hepatic disorders. Studies suggest that mitochondrial damage and oxidative stress are important mediators of toxicity, yet the underlying mechanisms are poorly understoo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jung, Seung-Hwan, Lee, Wonseok, Park, Seung-Hyun, Lee, Kang-Yo, Choi, You-Jin, Choi, Soohee, Kang, Dongmin, Kim, Sinri, Chang, Tong-Shin, Hong, Soon-Sun, Lee, Byung-Hoon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575798/ https://www.ncbi.nlm.nih.gov/pubmed/33080439 http://dx.doi.org/10.1016/j.redox.2020.101751

Ejemplares similares

Diclofenac: A Nonsteroidal Anti-Inflammatory Drug Inducing Cancer Cell Death by Inhibiting Microtubule Polymerization and Autophagy Flux
por: Choi, Soohee, et al.
Publicado: (2022)

Quantitative and qualitative analysis of autophagy flux using imaging
por: Kim, Suree, et al.
Publicado: (2020)

Involvement of Lysosomal Labilisation and Lysosomal/mitochondrial Cross-Talk in Diclofenac Induced Hepatotoxicity
por: Pourahmad, Jalal, et al.
Publicado: (2011)

RORα Enhances Lysosomal Acidification and Autophagic Flux in the Hepatocytes
por: Kim, Hyeon‐Ji, et al.
Publicado: (2021)

Three consecutive cytosolic glycolysis enzymes modulate autophagic flux
por: Lee, Du-Hwa, et al.
Publicado: (2023)

Stem cell-secreted 14,15- epoxyeicosatrienoic acid rescues cholesterol homeostasis and autophagic flux in Niemann–Pick-type C disease
por: Kang, Insung, et al.
Publicado: (2018)

Toosendanin Induces Hepatocyte Damage by Inhibiting Autophagic Flux via TFEB-Mediated Lysosomal Dysfunction
por: Luo, Li, et al.
Publicado: (2022)

Autophagic/lysosomal dysfunction in Alzheimer’s disease
por: Orr, Miranda E, et al.
Publicado: (2013)

Topical Diclofenac-Induced Hepatotoxicity
por: Delungahawatta, Thilini, et al.
Publicado: (2023)

Impaired Autophagic Flux in Glucose-Deprived Cells: An Outcome of Lysosomal Acidification Failure Exacerbated by Mitophagy Dysfunction
por: Hwang, Eun Seong, et al.
Publicado: (2023)

Triamterene induces autophagic degradation of lysosome by exacerbating lysosomal integrity
por: Park, Na Yeon, et al.
Publicado: (2021)

Targeted disruption of GAK stagnates autophagic flux by disturbing lysosomal dynamics
por: Miyazaki, Masaya, et al.
Publicado: (2021)

Autophagic and endo-lysosomal dysfunction in neurodegenerative disease
por: Malik, Bilal R., et al.
Publicado: (2019)

Is trehalose an autophagic inducer? Unraveling the roles of non-reducing disaccharides on autophagic flux and alpha-synuclein aggregation
por: Yoon, Ye-Seul, et al.
Publicado: (2017)

Indomethacin Disrupts Autophagic Flux by Inducing Lysosomal Dysfunction in Gastric Cancer Cells and Increases Their Sensitivity to Cytotoxic Drugs
por: Vallecillo-Hernández, Jorge, et al.
Publicado: (2018)

MERS-CoV nsp1 regulates autophagic flux via mTOR signalling and dysfunctional lysosomes
por: Feng, Yujie, et al.
Publicado: (2022)

Ubiquilins Regulate Autophagic Flux through mTOR Signaling and Lysosomal Acidification
por: Şentürk, Mümine, et al.
Publicado: (2019)

The Lysosomal Membrane Protein Lamp2 Alleviates Lysosomal Cell Death by Promoting Autophagic Flux in Ischemic Cardiomyocytes
por: Cui, Lin, et al.
Publicado: (2020)

A formulated red ginseng extract inhibits autophagic flux and sensitizes to doxorubicin-induced cell death
por: Park, Han-Hee, et al.
Publicado: (2019)

The phytochemical polydatin ameliorates non‐alcoholic steatohepatitis by restoring lysosomal function and autophagic flux
por: Chen, Xiaoting, et al.
Publicado: (2019)

Lysosomal dysfunction–induced autophagic stress in diabetic kidney disease
por: Zheng, Hui Juan, et al.
Publicado: (2020)

Gintonin stimulates autophagic flux in primary cortical astrocytes
por: Rahman, Md. Ataur, et al.
Publicado: (2020)

AB77. Tetrandrine blocks autophagic flux by preventing lysosomal acidification in 786-O cells
por: Gong, Yanqing, et al.
Publicado: (2014)

Endoplasmic reticulum stress disrupts lysosomal homeostasis and induces blockade of autophagic flux in human trophoblasts
por: Nakashima, Akitoshi, et al.
Publicado: (2019)

Autophagic Inhibition via Lysosomal Integrity Dysfunction Leads to Antitumor Activity in Glioma Treatment
por: Hwang, Hui-Yun, et al.
Publicado: (2020)

Inhibition of autophagic-lysosomal delivery and autophagic lactolysis by asparagine
Publicado: (1991)

The emerging role of autophagic-lysosomal dysfunction in Gaucher disease and Parkinson's disease
por: Kinghorn, Kerri J., et al.
Publicado: (2017)

Lysosomal basification and decreased autophagic flux in oxidatively stressed trabecular meshwork cells: Implications for glaucoma pathogenesis
por: Porter, Kristine, et al.
Publicado: (2013)

Skeletal muscle myotubes of the severely obese exhibit altered ubiquitin-proteasome and autophagic/lysosomal proteolytic flux
por: Bollinger, Lance M., et al.
Publicado: (2015)

Cyclosporine A blocks autophagic flux in tubular epithelial cells by impairing TFEB‐mediated lysosomal function
por: Li, Zhi‐hang, et al.
Publicado: (2021)

Dieckol Inhibits Autophagic Flux and Induces Apoptotic Cell Death in A375 Human Melanoma Cells via Lysosomal Dysfunction and Mitochondrial Membrane Impairment
por: Jo, Min-Hee, et al.
Publicado: (2022)

Autophagic lysosome reformation dysfunction in glucocerebrosidase deficient cells: relevance to Parkinson disease
por: Magalhaes, Joana, et al.
Publicado: (2016)

Restoration of Autophagic Flux Rescues Oxidative Damage and Mitochondrial Dysfunction to Protect against Intervertebral Disc Degeneration
por: Kang, Liang, et al.
Publicado: (2019)

Enhancing lysosomal biogenesis and autophagic flux by activating the transcription factor EB protects against cadmium-induced neurotoxicity
por: Pi, Huifeng, et al.
Publicado: (2017)

Iron Promotes Dihydroartemisinin Cytotoxicity via ROS Production and Blockade of Autophagic Flux via Lysosomal Damage in Osteosarcoma
por: Shen, Ying, et al.
Publicado: (2020)

Zinc enhances autophagic flux and lysosomal function through transcription factor EB activation and V-ATPase assembly
por: Kim, Ki-Ryeong, et al.
Publicado: (2022)

Development of Research into Autophagic Lysosome Reformation
por: Chen, Yang, et al.
Publicado: (2018)

Autophagic lysosome reformation in health and disease
por: Nanayakkara, Randini, et al.
Publicado: (2022)

The integral membrane protein ITM2A, a transcriptional target of PKA-CREB, regulates autophagic flux via interaction with the vacuolar ATPase
por: Namkoong, Sim, et al.
Publicado: (2015)

Mefenamic Acid-Upregulated Nrf2/SQSTM1 Protects Hepatocytes against Oxidative Stress-Induced Cell Damage
por: Lee, Wonseok, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_qjhvfa8qjtd5ff3mqhscbn0lcp