Wogonin reverses the drug resistance of chronic myelogenous leukemia cells to imatinib through CXCL12-CXCR4/7 axis in bone marrow microenvironment

BACKGROUND: In the current study, chronic myeloid leukemia (CML) cells (K562 and KU812) co-cultured with human bone marrow stromal cells (BMSCs) were significantly less sensitive to imatinib (IM). The activation of the CXCL12-CXCR4/7 axis plays an important role in the protective effect of the bone...

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Detalles Bibliográficos
Autores principales: Cao, Hanbo, Gao, Yuan, Wang, Ruixuan, Guo, Qinglong, Hui, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575956/
https://www.ncbi.nlm.nih.gov/pubmed/33145265
http://dx.doi.org/10.21037/atm-20-1166

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575956/
https://www.ncbi.nlm.nih.gov/pubmed/33145265
http://dx.doi.org/10.21037/atm-20-1166

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