Overexpression of DJ-1 alleviates autosomal dominant polycystic kidney disease by regulating cell proliferation, apoptosis, and mitochondrial metabolism in vitro and in vivo

BACKGROUND: DJ-1 is critical for the mitochondrial function associated with autosomal dominant polycystic kidney disease (ADPKD). We aimed to investigate DJ-1’s function in the pathogenesis of ADPKD. METHODS: DJ-1 was knocked-down in IMCD3 cells to evaluate the effects of DJ-1 on cell phenotype and...

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Detalles Bibliográficos
Autores principales: Li, Zhongxin, Zhou, Jingjing, Li, Yan, Yang, Fan, Lian, Xiaoying, Liu, Wenhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576093/
https://www.ncbi.nlm.nih.gov/pubmed/33241024
http://dx.doi.org/10.21037/atm-20-5761

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576093/
https://www.ncbi.nlm.nih.gov/pubmed/33241024
http://dx.doi.org/10.21037/atm-20-5761

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